Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways
نویسندگان
چکیده
Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor can prevent aims of this project were evaluate the mechanism inhibited EV-A71 virus and provide experiment basis for finding new antiviral drugs. In study, after treated with in infected Vero cells, viral replication was reduced, cell viability higher than group. Additionally, decreased apoptosis level inflammatory cytokines induced by cells. regulating ROS mediated signaling pathway inflammation achieve antiviral.
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ژورنال
عنوان ژورنال: Biocell
سال: 2022
ISSN: ['0327-9545', '1667-5746']
DOI: https://doi.org/10.32604/biocell.2022.017757